درون تنی = In Vivo in vivo

in vivo = درون تنی، آزمایش هایی که درون بدن انجام می شود

PALMITOYL OLIGOPEPTIDE: Palmitoyl Oligopeptide (also known as palmitoyl pentapeptide, Dermaxyl, Matrixyl and Matrixyl 3000) is an engineered amino-peptide that when added to a culture of fibroblasts (key skin cells), stimulates collagen, elastin and glucosaminoglycans production. These are the key components of healthy-looking skin. Clinically proven to reduce wrinkle depth by increasing hyaluronic acid and collagen production, Palmitoyl Oligopeptide (PO)is a synthetic protein that is a fragment of collagen combined with palmitic acid to make it more lipophillic, to improve its stability and to enhance its affinity towards human skin. As with Palmitoyl Pentapeptide-3, one could look at PO as a man-made precursor to collagen. PO was developed through research to identify a substance that would behave similarly to retinoic acid but without its drawbacks, especially in regards to synthesizing collagen. The reported results are as follows: In vitro: Increases collagen production by the fibroblasts by as much as 350%. Increases hyaluronic acid production by the fibroblasts by as much as 146%. In vivo: The following statistics were gathered using image analysis of volunteers who used crèmes containing a 3% concentration of Biopeptide-CL for 28 days. Surface roughness -- Reduced 17% Mean depth of wrinkles -- Reduced 23% Depth of main wrinkle -- Reduced 39% Skin thickness -- Increased 4%. The increase in skin thickness was considered especially notable and contrasts with the 6% reduction of the skin thickness that occurs after 10 years of aging. PO is a potent active cosmetic ingredient without the adverse effects (including irritation, dehydration or long-term toxicity and instability) characteristic of retinoids. Used in CSRx Lip Remodeling Treatment, Intensive Eye Therapy Creme, Firming Peptide Eye Creme,  and Fresh Pout Lip Balm. (cellularskinrx.com)

PALMITOYL PENTAPEPTIDE 3: Clinically proven to regenerate the skin's upper layers by stimulating collagen production, thus thickening the epidermis. Palmitoyl Pentapeptide-3 is a synthetic protein that is a fragment of the C-terminal portion of collagen I (the most common type of the nineteen forms of collagen) combined with palmitic acid to make it more lipophillic, to improve its stability and to enhance its affinity towards human skin. One could look at Palmitoyl Pentapeptide-3 as a man-made precursor to collagen I. When this protein is added to cultured human fibroblasts it enhances the synthesis of collagen I, collagen III and fibronectin. In vitro, Palmitoyl Pentapeptide-3 was found to stimulate collagen IV synthesis by 100-327% and to stimulate hyaluronic acidsynthesis by 267%. In vivo Palmitoyl Pentapeptide-3 was found to stimulate collagen synthesis by 30-117%. Image analysis determined the effect Palmitoyl Pentapeptide-3 had on wrinkled skin. The six-month results are listed below, though significant results were seen in two months. Results: Mean wrinkle depth -- Reduced 17% Surface area: deep wrinkles -- Reduced 68% Surface area: moderate wrinkles -- Reduced 51% Mean density of wrinkled area -- Reduced 47% Skin roughness -- Reduced 16% Main wrinkle volume -- Reduced 24%. These results show that Palmitoyl Pentapeptide-3 had a dramatic effect on reducing the quantity and depth of wrinkles. It also improved surface smoothness. (cellularskinrx.com)

in vivo
درون تنی، آزمایش هایی که درون بدن انجام می شود

 بررسی های مختلف نشان داده است که مواد موجود در رنگ مو سبب آسیب ژنتیکی در سلول های کشت داده شده به صورت برون تنی می گردد، اما در شرایط درون تنی چنین نتایجی دیده نشده است. با این وجود بسیاری از پزشکان، به ویژه در بیماران سرطانی تحت مداوا و یا درمان شده، استفاده از این فرآورده ها را توصیه نمی کنند. بررسی ایمنی محصولات آرایشی بهداشتی در سازمان غذا و دارو در حال حاضر برای بررسی ایمنی محصولات آرایشی بهداشتی تنها ابزارهایی که در اختیار است، برچسب اصالت و شماره پروانه بهداشتی ورود و ساخت کالا می باشد. سازمان غذا و داروی وزارت بهداشت ایران، ایمنی محصولات آرایشی بهداشتی را بر اساس قوانین اتحادیه اروپا بررسی و ارزیابی می کند. در زمینه مصرف درست و صحیح لوازم آرایشی بهداشتی، بروشورهایی در مدارس و دانشگاه ها توزیع شده و سخنرانی هایی توسط مدیران سازمان غذا و دارو از جلمه خانم دکتر رویا تالاری انجام شده تا فرهنگ صحیح استفاده از لوازم آرایش نهادینه شود.

 هدف از این مطالعه، ارزیابی اثر کرم ضدچروک حاوی کرونولاین بر ساختار پوست و مقایسه آن با پلاسیبو با یک روش in vivo می باشد. روش استفاده شده تصویربرداری با امواج فرکانس بالای فراصوت است. صداهای منعکس شده از لایه میان پوست (درم) نشات گرفته از لایه های مرزی بین رشته های کلاژن ، مایع غنی از آب احاطه کننده آنها و سلولها می باشد. تغییرات پژواک دهی را می توان انعکاسی از تغییر در ترکیب درصد بافت پیوندی دِرم دانست. «پژواک سنجی درم» را می توان به عنوان وسیله ای برای نشان دادن پیری پوست پیشنهاد کرد. روش آزمایش داوطلب زن سفیدپوست در رده سنی تا سال دارای پوستی سالم در این آزمایش شرکت کردند. داوطلبین یک کرم پلاسیبو بر روی ناحیه پنجه کلاغی (چروک های گوشه بیرونی چشم) یک طرف پیشانی و یک کرم حاوی درصد پلاسیبو را بر روی ناحیه پنجه کلاغی طرف دیگر پیشانی استفاده کردند. استفاده از این کرم ها به مدت روز و هر روز دو مرتبه انجام شد. پژواک سنجی پوست در روز صفر(D0) و روز (D168) انجام شد. از یک اسکنر فراصوت مگاهرتزی برای گرفتن تصویر از سطح مقطع پوست استفاده شد.

روشهای in vivo : آزمونهایی که در آن از بدن موجود زنده به عنوان محیط آزمایش استفاده می شود. تست های این روش عبارتند از:

بسیاری از کارشناسان عقیده دارند روشهای in vitro بر in vivo برتری دارند و بسیاری نیز بر عکس فکر می کنند در هر صورت این روشها می توانند مکمل یکدیگر باشند.

PALMITOYL OLIGOPEPTIDE: Palmitoyl Oligopeptide (also known as palmitoyl pentapeptide, Dermaxyl, Matrixyl and Matrixyl 3000) is an engineered amino-peptide that when added to a culture of fibroblasts (key skin cells), stimulates collagen, elastin and glucosaminoglycans production. These are the key components of healthy-looking skin. Clinically proven to reduce wrinkle depth by increasing hyaluronic acid and collagen production, Palmitoyl Oligopeptide (PO)is a synthetic protein that is a fragment of collagen combined with palmitic acid to make it more lipophillic, to improve its stability and to enhance its affinity towards human skin. As with Palmitoyl Pentapeptide-3, one could look at PO as a man-made precursor to collagen. PO was developed through research to identify a substance that would behave similarly to retinoic acid but without its drawbacks, especially in regards to synthesizing collagen. The reported results are as follows: In vitro: Increases collagen production by the fibroblasts by as much as 350%. Increases hyaluronic acid production by the fibroblasts by as much as 146%. In vivo: The following statistics were gathered using image analysis of volunteers who used crèmes containing a 3% concentration of Biopeptide-CL for 28 days. Surface roughness -- Reduced 17% Mean depth of wrinkles -- Reduced 23% Depth of main wrinkle -- Reduced 39% Skin thickness -- Increased 4%. The increase in skin thickness was considered especially notable and contrasts with the 6% reduction of the skin thickness that occurs after 10 years of aging. PO is a potent active cosmetic ingredient without the adverse effects (including irritation, dehydration or long-term toxicity and instability) characteristic of retinoids. Used in CSRx Lip Remodeling Treatment, Intensive Eye Therapy Creme, Firming Peptide Eye Creme,  and Fresh Pout Lip Balm. (cellularskinrx.com)

PALMITOYL PENTAPEPTIDE 3: Clinically proven to regenerate the skin's upper layers by stimulating collagen production, thus thickening the epidermis. Palmitoyl Pentapeptide-3 is a synthetic protein that is a fragment of the C-terminal portion of collagen I (the most common type of the nineteen forms of collagen) combined with palmitic acid to make it more lipophillic, to improve its stability and to enhance its affinity towards human skin. One could look at Palmitoyl Pentapeptide-3 as a man-made precursor to collagen I. When this protein is added to cultured human fibroblasts it enhances the synthesis of collagen I, collagen III and fibronectin. In vitro, Palmitoyl Pentapeptide-3 was found to stimulate collagen IV synthesis by 100-327% and to stimulate hyaluronic acidsynthesis by 267%. In vivo Palmitoyl Pentapeptide-3 was found to stimulate collagen synthesis by 30-117%. Image analysis determined the effect Palmitoyl Pentapeptide-3 had on wrinkled skin. The six-month results are listed below, though significant results were seen in two months. Results: Mean wrinkle depth -- Reduced 17% Surface area: deep wrinkles -- Reduced 68% Surface area: moderate wrinkles -- Reduced 51% Mean density of wrinkled area -- Reduced 47% Skin roughness -- Reduced 16% Main wrinkle volume -- Reduced 24%. These results show that Palmitoyl Pentapeptide-3 had a dramatic effect on reducing the quantity and depth of wrinkles. It also improved surface smoothness. (cellularskinrx.com)